Dayton Children's Clinical Trials - Dayton Children's Clinical Trials is a division of The Children's Medical Center of Dayton.

Research Report - 2006 - 2007

Physicians affiliated with Dayton Children's and the Wright State University Boonshoft School of Medicine's department of pediatrics (located at Dayton Children's) are continually involved in clinical research activities, actively contributing to the body of knowledge that will improve treatment for the region's infants, children and teens.

Growing by leaps and bounds...
Research activity blossoms!

So that children can continue to grow by leaps and bounds, our research activities must continue to grow as well. Dayton Children’s is proud to report that academic and hospital research activities have blossomed, making 2006 – 2007 a year of growth.

Research at Dayton Children’s is conducted by:

• Physicians and staff affiliated with Wright State University (WSU) Boonshoft School of Medicine department of pediatrics
• Physicians and staff of Dayton Children’s
• Dayton Children’s Pediatric Clinical Trials (DCCT)

Highlights of 2006 – 2007

Quality initiatives

• Dayton Children’s earned a national quality and safety award—the 2006 “Race for Results” award for its success in reducing bloodstream infections in the pediatric intensive care unit (PICU). Congratulations to Jodi Mullen, RN; Mark Rowin, MD; Thomas Murphy, MD; Tami Wiggins, RN; Hila Collins, RN; and Karen Rittenhouse, RN.
• Dayton Children’s received full accreditation from the Joint Commission for the Accreditation of Healthcare Organizations (JCAHO).  This was the first survey since JCAHO began their unnanounced visits.

Medical education

• Over 18% of WSU Boonshoft School of Medicine students chose pediatrics, internal medicine/pediatrics or emergency medicine/pediatrics as their specialty, making pediatrics the first choice of the class of 2007.
• Dayton Children’s Residents (and WSU medical students) present papers/posters at major national meetings in multiple specialties!
• Endocrinology course (MS II) again named as one of the best organized and informative courses. 
   

Research

• WSU faculty and members of Dayton Children’s professional staff continue to publish outstanding papers in peer-reviewed journals and continue to be very well represented at major national meetings in multiple specialties at which they presented papers and posters.
• Dayton Children’s residents and WSU medical students present papers/posters at major national meetings in multiple specialties.
  

WSU Department of Pediatrics Academic Activity Summary 2006
Arthur S. Pickoff, MD, Professor and Chair

Grants and contracts

Sherman Alter, MD, director of infectious disease

•  Prevention of RSV infection with a monoclonal antibody therapy (NUMAX®).  MedImmune. Co-investigator.
• Immunogenicity and safety of meningococcal (Groups A, C, Y, and W-135)  diphtheria conjugate vaccine Menactra®) in adolescents in the US when administered concomitantly with tetanus and diphtheria toxoids adsorbed combined with component pertussis (TdcP) vaccine.  Sanofi Pasteur.  Principal investigator

Emmett H. Broxson, MD, director of hematology/oncology

• Principal Investigator at The Children’s Medical Center of Dayton for Children’s Oncology Group 2000-present.
• Fibrinogen concentrate (HaemocomplettanP) for congential hypofibrogenemia. 2005-present.
• Co-investigator in Exjade study 2005-2006

Mukund Dole, hematology/oncology

• Region II comprehensive sickle Cell Program Funding Ohio Department of Health
• Principle Investigator, Exjade study

Greg Eberhart, MD

• Children’s Foundation – Social Capital Scale

Robert Fink, MD, director of pulmonary medicine

• “A phase 3, double-blind, multicenter, randomized, placebo-controlled trial with aztreonam lysinate for inhalation (AI) in cystic fibrosis patients with pulmonary aeruginosa requiring frequent antibiotics” Funded by Corus Pharma, Inc.  PI 5% Effort. 2005 - present
• “The EPIC observational study: longitudinal assessment of risk factors for the impact of pseudomonas aeruginosa acquisition and early anti pseudomonal treatment in children with CF” Funded by Cystic Fibrosis Foundation Therapeutics, Inc.  PI 5% Effort. 2005 - present
• “The EPIC clinical study: effectiveness and safety of intermittent antimicrobial therapy for treatment of new onset pseudomonas aeruginosa (Pa) airway infection in young patients with cystic fibrosis” Funded by Cystic Fibrosis Foundation Therapeutics, Inc.  PI 5% Effort. 2005 - present
• “A randomized, open-label, multicenter, phase 3 trial to assess the safety of tobramycin inhalation powder (TIP) compared to TOBI in cystic fibrosis subjects”.  Funded by Chiron Corporation  PI 5% Effort. 2006 - present
• “A phase 3, open-label, follow-on study of aztreonam lysinate for inhalation (AI) in cystic fibrosis patients”.  Funded by Corus Pharma, Inc.  PI 5% Effort. 2006 - present
  

Shalini Forbis, MD, children's health clinic

• AAP CATCH GRANT - Health care access through health literacy.
• Health Resources and Services Administration, Academic Administrative Unit Grant, Co-investigator. 
   

James French, MD, hematology/oncology 

• A phase II/III clinical study for the determination of the efficacy and safety of protein C concentrate in subjects with severe congenital protein C deficiency. Sponsor: Gaxter
• Retrospective study to describe the incidence of moderate-severe allergic reaction to factor 1X concentrate in patients with hemophilia B.  Sponsor: Wyeth Research
• Open label multicenter study to assess the efficacy and safety of B-domain deleted recombinant factor VIII in patients with hemophilia A.  Sponsor: Wyeth Research
• Assessment of the risk of inhibitor formation in subjects with severe hemophilia A when switched from a replacement therapy with a rFVIII produced by a chinese hamster ovary (CHO) cell line to a rFVIII produced by a baby hamster kidney (BHK) cell line (Kogenate® FS).
• Co-investigator, COG studies.
• The second multicenter hemophilia cohort study (MHCS-11).
• A phase III, open-label, single-arm study of tenecteplase for restoration function in dysfunctional central venous catheters.
• Thromboembolism registry, HTRS

Daniel Lacey, MD, PhD, child neurology 

• An evaluation of the therapeutic effectiveness of hyperbaric oxygen treatments on children with cerebral palsy, US Dept. of Defense and the Army Medical R&D Command;  Principal Investigator

Sonia Michail, MD, gastroenterology and nutrition

• Ion transport changes in the colonic crypts in children with inflammatory bowel disease National Institutes of Health, Collaborating Investigator (Dr. Dan Halm, WSU department of physiology and biophysics, PI).
• Design and implementation of custom GeneChip community microarray to study human microflora, Co-PI

Gary Mueller, MD, pulmonary medicine

• Efficacy of pulmozyme in infants and young children with cystic fibrosis.  Co-investigator.  Grant organization: Genentech Inc

Maria Nanagas, MD, children's health clinic 

• Parent education on health care at CHC; develop and implement grant, Reynolds and Reynolds
• Reach out and read program
  

Gary Onady, MD

• Cystic Fibrosis Foundation Center grant, adult cystic fibrosis program, Dayton, Ohio

• Academic Administrative Unit, Pediatrics Health Resources and Services Administration (Training in primary care medicine and dentistry)  – Project director.
• Parents’ social capital and their child health behavior: A longitudinal study of the Dayton primary care Practice-based Research Network (PBRN) – Co-PI; Dayton Children’s Research Foundation.

James Stark, pulmonary medicine

• New Investigator Award, Boonshoft School of Medicine, WSU Genetic Determinants of RSV Susceptibility in Mice.

Adrienne Stolfi, MSPH, biostatistician, WSU Boonshoft School of Medicine 

• An evaluation of the therapeutic effectiveness of hyperbaric oxygen treatments on children with cerebral palsy; department of defense; Co-investigator (Statistician).

Maria Urban, MD, endocrinology and metabolism 

Post-marketing growth hormone studies:

• KIGS study (sponsored by Pharmacia/Pfizer Co.)
• Growth hormone monitor (sponsored by Serono Co.)
• GeNeSIS Study (sponsored by Lily Co.)
• NCGS study (sponsored by Genentech Co.)
• Norditropin study (sponsored by NovoNordisk)

Publications and papers

Patricia Abboud, MD, Ancheta R, McKibben M, Jacobs BR.  Clinical Informatics Outcomes Research Groups.  Impact of workflow-integrated corollary orders on aminoglycoside monitoring in children.  Health Informatics Journal 2006; 12:187-198. 

Matloub Y, Lindemulder S, Gaynon PS, Sather H, La M, Emmett Broxson, MD, Yanofsky R, Hutchinson R, Heerema NA, Nachman J, Blake M, Wells LM, Sorrell AD, Materson M, Kelleher JF, Stork LC.  Intrathecal triple therapy prevents central nervous system event-free survival when compared to intrathecal methotrexate: Results of the Children’s Cancer Group (CCG) 1952 study for standard-risk acute lymphoblastic leukemia, reported by the Children’s Oncology Group.  Blood. 2006,108:1165-73.

McPhillips HA, Anne Burke, MD, Sheppard K, et al.  Toward creating a family-friendly work environment in pediatrics: Baseline data from pediatric department chairs and pediatric program directors, Pediatrics 2007; 119;596-602.

Shanlini Forbis, MD, Rammel J, Huffman B, Taylor R.  Barriers to care of inner-city children: School nurse perspective.  J Sch Health. 2006 Aug;76(6):205-7.

Shalini Forbis, MD, McAllister T, Monk S, Schlorman C, Adrienne Stolfi, MSPH, John Pascoe, MD.  Children and firearms in the home:  A Southwestern Ohio Ambulatory Research Network (SOAR-Net) Study. JABFM (Accepted for publication, January 2007).

Adam Mezoff, MD, Preud’Homme D, Hodges C, Milliken T, and Sonia Michail, MD.  Capsule endoscopy in pediatric patients with hamartomatous polyp syndromes. J Pediatr Gastroenterol 42:240-242, 2006.

Preud’Homme DL,Sonia Michail, MD, Hodges C, Milliken T, Adam Mezoff, MD.  Use of wireless capsule endoscopy in the management of severe Henoch Schoenlein Purpura.  Pediatrics 118:e904-906, 2006.

Otley AR, Griffiths AM, Hale S, Kugathasan S, Pfefferkorn M, Adam Mezoff, MD, Rosh J, Tolia V, Markowitz J, Mack D, Oliva-Hemker M, Wyllie R, Rothbaum R, Bousavaros A, Del Rosario JF, Blanchard W, Hyams J; Pediatric IBD Collaborative Research Group.  Health-related quality of life in the first year after diagnosis of pediatric inflammatory bowel disease. Inflamm Bowel Dis 12:684-91,2006.

Markowitz J, Hyams J, Mack D, Leleiko N, Evans J, Kugathasan S, Pfefferkorn M, Adam Mezoff, MD, Rosh J, Tolia V, Otley A, Griffiths A, Moyer MS, Oliva-Hemker M, Wyllie R, Rothbaum R, Bousvaros A, Del Rosario JF, Hale S, Lerer T; Pediatric IBD Collaborative Research Group.  Corticosteroid therapy in the age of infliximab: Acute and 1 year outcomes in newly diagnosed children with Crohn’s disease. Clin Gastroenterol Hepatol. 2006 Sept;4 (9):1124-9.

Hyams J, Markowitz J, Lerer T, Griffiths A, Mack D, Bousvaros A, Otley A, Evans J, Pfefferkorn M, Rosh J, Rothbaum R, Kugathasan S, Adam Mezoff, MD, Wyllie R, Tolia V, delRosario JF, Moer MS, Oliva-Hemker M, Keleiko N: Pediatric Inflammatory Bowel Disease Collaborative Research Group.  The natural history of corticosteroid therapy for ulcerative colitis in children.  Clin Gastroenterol Hepatol. 2006 Sept;4(9):118-23. 

Sonia Michail, MD. Gastroesophageal reflux. Pediatrics in Review, March 2007.

Sonia Michail, MD, Sylvester F, Fuchs G, Issenman R. Clinical efficacy of probiotics:  Review of the evidence with a focus on children. J Pediatr Gastroenter Nutr 43: 550-557, 2006.

Sonia Michail, MD, Fuchs G, Slyvester F. Issenman R. ‘Clinical efficacy of probiotics: Response to letter to the editor’.  J Pediatr Gastroenter Nutr (in press).

Marvin Miller, MD, Using DNA testing to provide information on marfan syndrome.  Pediatric Clips, March 2006.

Abiodun Omoloja, MD , Adrienne Stolfi, MPHS, Mitsnefes M.  Racial differences in pediatric renal transplantation – 24-year single center experience.  J Natl Med Assoc 98:154-157, 2006.

Gary Onady, MD, Adrienne Stolfi, MPHS. Insulin and oral agents for managing cystic fibrosis-related diabetes.  The Cochrane Database of Systematic Reviews, 2006, Issue 6, John Wiley & Sons, Ltd.

Gary Onady, MD, Farinet CL.  An adult cystic fibrosis patient presenting with persistent dyspnea: case report. BMC Pulm Med. 2006;6:9.

Gary Onady, MD, Langdon LJ. Insulin versus oral agents in the management of cystic fibrosis related diabetes: A case based study. BMC Endocr Disord. 2006;Jun 21;6:4.

Demerath EW, Schubert CM, Maynard LM, Sun SS, Chumlea WC, Arthur Pickoff, MD, Czerwinski SA, Towne BA, Siervogel RM. Do changes in body mass index percentile reflect changes in body composition in children? Data from the Fels Longitudinal Study. Pediatrics 117(3):487-495, 2006.

Susan Monk, MD, Maria Nanagas, MD, Jody Fitch, Adrienne Stolfi, MPHS, Arthur Pickoff, MD. Comparison of resident and faculty patient satisfaction surveys in a pediatric ambulatory clinic. Teaching and Learning in Medicine, 18(4):343-347, 2006.

Sun S, Grave GD, Siervogel R, Arthur Pickoff, MD, Arslanian SS, Daniels SR, Systolic blood pressure in children predicts hypertension and the metabolic syndrome later in life. Pediatrics, 119:237-246, 2007.

Marc Raslich, MD, Gary Onady, MD.  Evidence-based medicine – Critical Appraisal of the Literature (Appraisal Tools).  Pediatrics In Review, April 2007.

Gary Onady, MD, Donnelly JR, Prochaska LJ, Prochaska LJ, Paietta JV, Parmelee DX, Schuster B, (2006) Mechanisms of Sickle Cell Anemia.  MedEdPORTAL; Available from http://www.aamc.org/mededportal, ID = MEP 265. 

John Pascoe, MD, Adrienne Stolfi, MPHS; Ormond, Mary B.  Correlates of mothers’ persistent depressive symptoms: a national study.  Journal of Pediatric Health Care. 2006;4:261-9.

Marc Raslich, MD,  2nd edition, Pediatric Clinical Advisor, Hypertension and Sinusitis chapters (in press).

Colasurdo GN, Fullmer JJ, Elidemir O, Atkins C, Khan AM, James Stark, MD.  Respiratory syncytial virus infection in a murine model of cystic fibrosis. J Med Virol. 2006;78:651-8.

Hardin DS, Adams-Huet B, Brown D, Chatfield B, Maynard D, Ferkol T, Howenstine M, Prestidge C, Fredrick Royce, MD,  Rice J, Seilheimer DK. Growth hormone treatment improves growth and clinical status in prepubertal children with cystic fibrosis: Results of a multicenter randomized controlled trial. Journal of Clinical Endorcinology & Metabolism 91(12):4925-4929, 2006.

James Stark, MD, Stark MA, Colasurdo GN, LeVine AM.  Decreased pulmonary clearance of streptococcus pneumoniae following respiratory syncytial virus infection in mice.  J Med Virol 2006;78:827-838.

James Stark, MD.  Models for the study of respiratory syncytial virus infection and disease. Drug Discovery Today: Disease Models 2006;3:63-68 (epub).

Hicks RA, Adrienne Stolfi, MPHS .  Skeletal surveys in children with burns due to child abuse. Pediatr Emerg Care (In Press).

Amit Vohra, MD  – Management of Diabetic Ketoacidosis. Pediatric Clips, Nov. 2006. 

Books and chapters

Patricia Abboud, MD, Wheeler DS, Raake J.  Supplemental Oxygen Administration and Bag-Valve-Mask Ventilation.  In: ST Wheeler DS, H Wong, WH Eds.  Pediatric Critical Care Medicine: Basic Science & Clinical Evidence.  1st ed.  Springer-Verlog Publishing, Inc., London, UK:2007.

Powers KS, Cholette JM, Patricia Abboud, MD.  Toxic Exposures: Diagnosis and Management  In: T Shanley, DS Wheeler, H Wong, Eds.  Pediatric Critical Care Medicine: Basic Science & Clinical Evidence.  1st ed. Springer-Verlog Publishing, Inc., London, UK:2007.

Preud’Homme DL, Adam Mezoff, MD: Bezoars. In: Wyllie R, Hyams JS, eds.  Pediatric Gastrointestional and Liver Disease – Pathophysiology, Diagnosis, Management  Ed. 3 W.B. Saunders Company 2006, pps 451-455.

Sonia Michail, MD (Editor), Pediatric Probiotic Medicine.  Co-editor Phillip Sherman, Humana press, in preparation.

Talente G., Gary Onady, MD, Evidence-based Medicine for the Pediatrician. Eds. Perkin RM, Swift JD, Newton DA.  Pediatric Hospital Medicine: Textbook of Inpatient Management.  Lippincott, Williams & Wilkins. PA,. 2nd Ed, 2006. 

Haidet P, Schneider V, Gary Onady, MD.  Team-Based Learning Research in Health Professions Education.  Ed. Parmelee DX.  Stylus Publishing, LLC. (In Press).

John Pascoe, MD, Shaikh U, Etzel RA, Shalini Forbis, MD.  Health and Nutrition as a Foundation for Success in School.  In: School Readiness, Early Learning, and the Transition to Kindergarten.  Brookes Publishing Co:  Towson, Maryland.  (in press).

Arthur Pickoff, MD.  Developmental Cardiac Electrophysiology and the Cardiac Conduction System.  In:  Polin RA, Fox WW (Eds): Fetal and Neonatal Physiology, 4rd Edition.  Philadelphia, W.B. Saunders. (in press)

Mark Rowin, MD. Nosocomial Infections within the Pediatric Intensive Care Unit, in Pediatric Multiprofessional Critical Care Review, Conway Jr EE and Relvas MS, Editors. Society of Critical Care Medicine, Des Plaines IL, 2006.

Mark Rowin, MD.  Immunodeficiencies in the Pediatric Intensive Care Unit, in Pediatric Multiprofessional Critical Care Review, Conway Jr EE and Relvas MS, Editors. Society of Critical Care Medicine, Des Plaines IL, 20069.

Mark Rowin, MD. Pediatric Ventilator-Associated Pneumonia, in Current Concepts in Pediatric Critical Care, Conway Jr EE, editor. Society of Critical Care Medicine, Des Plaines IL, 2006.

James Stark, MD and Colasurdo GN.  Lung Defenses. In: Chernick V, Boat TF, Wilmott WW, Bush A, Eds. Disorders of the Respiratory Tract in Children, 7th Edition. WB Saunders Co. Philadelphia, PA, 2006. Chapter 12, pp205-223.

Abstracts – platform and poster presentations 

“Therapeutic Effect of Epigallocatechin Gallate (EGCG) in a Mouse Model of Inflammatory Bowel Disease.”  Patricia Abboud, MD, Hake P, Burroughs T, Odoms K, Michael O’Connor, Wong HR, Zingaelli B. Society of Critical Care Medicine Educational and Scientific Sympsium, San Francisco, CA. January 7-11, 2006.  Critical Care Medicine, Volume 33, Issue 12 (Suppl.): A 21, 2005.

Ann Burke, MD, Curriculum Task Force: Interactive Symposium of Curricular Tools for Practice Based Learning and Improvement. Burke A, Englander R. APPD Annual Spring Meeting, San Francisco. April 28, 2006.

Ann Burke, MD, Pallant A. Exploring the Family Friendly Workplace: The FOPO Report of the Task Force on Women. APPD Annual Spring Meeting, San Francisco. May 28, 2006.

Ann Burke, MD, Pallant A. The Individualized Learning Plan and Portfolio: Skills for Adult Learners and Requirements for the RRC. APPD Fall Meeting, Reston, VA, October 2006.

Ryan Carvalho, MD - Crohn’s and Colitis Family Education Day: Ask the Experts.  Breakout session on Medications in IBD.

Shalini Forbis, MD - Ohio Asthma Coalition Biennial Asthma Education Conference..  “Health Literacy: A Key to Asthma Education”, Plenary Speaker, March 10, 2006.

Mesghali S, Elviria Jaballas, MD, Clasen C, Adrienne Stolfi, MPHS , Hadley J, Maria Urban, MD, Clark D.  Parents’ Perceptions of their Children’s Weight, Eating Habits, and Physical Activities at Home and at School.  Pediatric Academic Societies Annual Meeting.

Hadley J, Elviria Jaballas, MD, Clasen C, Adrienne Stolfi, MPHS, Mesghali S, Maria Urban, MD, Clark D.  Parents’ Perceptions, Attitudes, and Concerns About Obesity in Their Children.  Pediatric Academic Societies.

Elvira Jaballas, MD. Generalist in Medical Education Annual Conference, Seattle, Washington, October 28, 2006.  “Resident and Student Initiated Multidisciplinary Study of Parents’ Perceptions of Childhood Obesity”.

Elvira Jaballas, MD. “Resident Initiated Incorporation of an Established Early Literacy Model into Clinical Practice”

Daniel Lacey, MD - Presentation at TATRC/MRMC Product Line Review, Fort Detrick, MD March 7, 2006, Hyperbaric Oxygen in Cerebral Palsy Grant.

Shalni Forbis, MD, Adrienne Stolfi, MPHS, Schlorman CA, McAllister TR, John Pascoe, MD.  Attitudes Regarding Physician Counseling on Gun Safety Practices: A Comparison Between Military and Civilian Parents.  E-PAS 2006:59:2912.429.

Mendel SG, John Pascoe, MD, Adrienne Stolfi, MPHS, Duby JC, Doyne E.  Is State of the Art the State of Things?  Diagnosis and Management of ADHD by AAP Pediatricians in Ohio.  E-PAS2006:59:4860.338.

John Pascoe, MD, Shalini Forbis, MD, Adrienne Stolfi, MPHS, Schlorman CA, McAllister TR.  Parental Gun Storage Patterns and Attitudes about Gun Safety Counseling and Gun Safety Education.  AHRQ Annual PBRN Meeting, May 2006 35, Bethesda, MD. 

John Pascoe, MD, Shalini Forbis, MD, Adrienne Stolfi, MPHS, Schlorman CA, McAllister TR.  Attitudes Regarding Physician Counseling on Gun Safety Practices: A Comparison Between Military and Civilian Parents.  AHRQ Annual PBRN Meeting, May 2006, 91, Bethesda, MD.

Gupta RS, John Pascoe, MD, Southward LH, Duncan P, Gorski P, Greenberg R.  Child Health Beliefs and Behaviors of Child Care Directors: Head Start vs. Non-Head Start Centers.  Head Start Eighth National Research Conference, June 26-28, 2006 (Washington, DC).

Cauley KL, Crimmins MM, John Pascoe, MD.  Regional Health Information Organizations: Building on Collaboration, American Public Health Association 134th Annual Meeting & Exposition (November 4-8, 2006) Boston, MA.

Crimmins MM, Cauley KL, Arthur Pickoff, MD, John Pascoe, MD.  Community Child Health Record: Sharing Data Across Organizations.  American Public Health Association 134th Annual Meeting & Exposition (November 4-8, 2006) Boston, MA.

Punati JB, Markowitz J, Lerer T, Hyams J, Kugathasan S, Griffiths A, Otley A, Rosh J, Pfefferkorn M, Mack D, Evans J, Bousaros A, Moyer S, Rothbaum R, Wyllie R, Tolia V, Olive-Hemker M, Adam Mezoff, MD, Leliekos N, del Rosario J, Keljo D, Crandal W.  Early Immunomodulator Use Improves 18 Month Outcomes in Pediatric Crohn’s Disease.  Gastroenterology 130:11 (55), 2006.ohn Pascoe, MD, Maria Nanagas, MD, Shalini Forbis, MD. African-American families’ perceptions of important child health issues: Comparison of a community vs. a clinic population. 45th Annual PAS meeting, Pediatr Res 2005;57:887.

Pfefferkorn M, Hyamus J, Burke G, Markowitz J, Rosh K, Mack D, Otley A, Kugathasan S, Evans J, Bousvaros A, Moyer S, Rothabum R, Wyllie R, Oliva-Hemker  M, Adam Mezoff, MD, LeLeiko N, del Rosario F, Crandall W, Kelijo D, Baldassano R, Griffiths A.  Growth Failure Persists Despite Current Treatment Paradigms in Pediatric Crohn Disease.  Gastroenterology 130:191 (s1271), 2006.

Rosh JR, Hyams J, Lerer T, Markowitz J, Pfefferkorn M, Mack D, Otley A, Kugathasan S, Evans K, Bousvaros A, Moyer S, Rothbaum R, Wyllie R, Tolia V, Oliva-Hemker M, Adam Mezoff, MD, LeLeiko N, del Rosario F, Crandall W, Keljo D, Baldassano r, Griffiths A.  Outcome of Moderate to Severe Pediatric Crohn Disease; Effect of Infliximab Therapy.  Gastroenterology 130:192 (s1278)11, 2006.

Sonia Michail, MD, Adam Mezoff, MD.  Joint Hypermobility and Rectal Prolapse in Children.  Gastroenterology 130:264, 2006. 

Sonia Michail, MD,  Abernathy F.  Lactobacillus GG Inhibits Neutrophil Migration by Regulating Chemokine Receptor – 2 gene.  JPGN 2006, 43:E16.

Hangartner TN, Varghese B and Marvin Miller, MD (2006): Analysis of Pediatric Radiographs of Forearms – Morphologic Differences that Separate Children Suffering from Fractures due to Unintentional Injury or Intentional Injury.  Proceedings of The Fourth Clare Valley Bone Meeting, Clare Valley, South Australia: O16 and Proceedings of World Congress on Medical Physics and Biomedical Engineering 2006, Soul, Korea.

Marvin Miller, MD.  “Broken Bones and Broken Families”  Presentation at symposium sponsored by the Eaton Foundation “The Wrongful Diagnosis of Child Abuse – an American Perspective”, London, England, May 16, 2006.

Marvin Miller, MD.  “Brittle Bone Disease, Bone Density and OI or is it Child Abuse?”  Presented at the Annual Southern Pediatric Endocrine Society Conference, Birmingham, Alabama, November 12, 2006.

Gary Mueller, MD, Adrienne Stolfi, MPHS, Langdon L, Driscoll C, Fink RJ.  Increase in Percent Change Per year FEVI Described by Starting FEVI and Age at a CF Center with High Rates of Chronic Therapy Use.  Twentieth Annual North American Cystic Fibrosis Conference, Denver, CO, Nov. 2006.  Pediatric Pulmonology, Supplement 29, 2006.

Langdon LJ, Driscoll CL, Adrienne Stolfi, MPHS, Robert Fink, MD, Fredrick Royce, MD, Gary Mueller, MD, Gary Onady, MD, Lemming C, Butschillinger M, Nelson S.  Caregivers’ Perceptions of Lung Function: Are We Seeing the Real Picture?  Abstract 566, 20th Annual North American Cystic Fibrosis Conference, Denver Colorado, November 2nd, 2006.

Mark Rowin, MD. “The Role of Pediatric Advanced Life Support Training in Out of Hospital Pediatric Resuscitations” Pediatric Academic Society Annual Meeting, San Francisco, CA, May 2006.

Fredrick Royce, MD, Bush A, Gary Mueller, MD. “Should Lobectomy be Performed When CF-associated Lung Disease is Focal and Rapidly Progressive, 2006 North American Cystic Fibrosis Conference, 11/02/06, Denver, Physician Grand Rounds Presentation, Ped Pulm, Suppl. 29 (2006).

John CK, James Stark, MD, Khan AM, Alcorn JL, Atkins BS, Xue H, Schecter MG, Larsen GL, Colasurdo GN.  Genetic Susceptibility to RSV Infection in Inbred Mouse Pups: Important Role of SP-A.  Proc Am Thoracic Soc 2006: A411. American Thoracic Society International Meeting, San Diego, CA May 19-24, 2006.

Lawson JK, Colasurdo GN, Atkins CL, Khan AM, Schecter MG, James Stark, MD.  Exposure of Newborn Mice to LPS Protects from Allergen (Ovalbumin) – Induced Airway Hyperresponsiveness and Airway Remodeling Independent to TH1/TH2 Pathways. Proc AM Thoracic Soc 2006; 3: A153. American Thoracic Society International Meeting, San Diego, CA May 19-24. 2006

James Stark, MD, Jon CK, Khan AM, Atkins BS, Stark MA, Xue H, Larsen GL, Colasurdo GN.  Effect of Genetic Background and Age on Airway Responsiveness Following RSV Infection in Inbred Mouse Pups.  Proc Am Thoracic Soc 2006; 3:412. American Thoracic Society International Meeting, San Diego, CA May 19-24, 2006.

Schecter MG, Morandi M, Holian A, Khan AM, Atkins CL, Jon CK, James Stark, MD, Colasurdo GN.  Functional and Cellular Response to Lipopolysaccharide and Particulate Matter (PM-1648 and PM-Hou) in Developing Mice.  Proc Am Thoracic Soc 2006; 3: A553. American Thoracic Society International Meeting, San Diego, CA May 19-24. 2006.

Rios EH, James Stark, MD, Jenkins GN, Alcorn JL.  The Presence of an Amino or Carboxy-Terminal FLAG-tag has no Effect on Biosynthesis, Oligomerization and Secretion of Surfactant Protein-A (SP-A). PAS meeting 2007, Toronto, Canada.

James Stark, MD, Prows DR, Leikauf GD.  Genetic Determinants of Respiratory Syncytial Virus (RSV) Susceptibility in Inbred Mice. American Thoracic Society International Meeting, San Francisco, CA May 18-23, 2007.

Alcorn JL, Atkins CL, Khan AM, James Stark, MD, Colasurdo GN.  Regulation of Surfactant Protein-A (SP-A) Protein in Human Lung Epithelial Cells after Infection by Respiratory Syncytial virus (RSV). American Thoracic Society International Meeting, San Francisco, CA May 18-23, 2007.

Reverdin AK, Khan AM, Dsa S, Atkins CL, Jon CK, Colasurdo GN, Alcorn JL, James Stark, MD.  Determinant of Disease Severity after RSV Infection in Young and Aged Mice. American Thoracic Society International Meeting, San Francisco, CA May 18-23, 2007.

Reverdin AK, James Stark, MD, Khan AM, Atkins CL, Jon CK, Larden GL and Colasurdo GN.  Susceptibility to RSV Infection and Persistent Airway Dysfunction in Inbred Mouse Pups: Influence of Genetic Background and Host Response. American Thoracic Society International Meeting, San Francisco, CA May 18-23, 2007.

Jon CK, James Stark, MD, Khan AM, Alcorn JL, Atkins CL, Schecter MG, Reverdin AK and Colasurdo GN.  Genetic Susceptibility to RSV in Inbred Mouse Pups: Role of Leukotriene Signaling. Accepted, American Thoracic Society International Meeting, San Francisco, CA May 18-23, 2007.

Preud’Homme DL, Adrienne Stolfi, MPHS.  Fasting Glucose to Insulin Ratio is Sensitive but not Specific for Predicting Impaired Glucose Tolerance in Severely Obese Children.  Circulation 113:E344, 2006  

Preud’Homme DL, Adrienne Stolfi, MPHS.  Children with Obesity are Unable to Follow Recommended Guidelines for Exercise.  Circulation 113:E356, 2006.

Preud’Homme DL, Adrienne Stolfi, MPHS, Reuland C, Bethell C.  Prevalence of Overweight and Obesity in a Population of Low Income Toddlers Aged 24-45 Months in Ohio: Influence of Maternal Factors.  Circulation 113:E355-E356, 2006.

Mark Rowin, MD, Soto W, King W, Baker T, Adrienne Stolfi, MPHS.  The Role of Pediatric Advanced Life Support Training in Out of Hospital Pediatric Resuscitations. E-PAS2006:59:4836.121.

Significant presentations

Cecilia Amisola, MD

• “Autism” – Community Family Practice Residency Program, Good Samaritan Hospital, March 29, 2006.
• “Alternative treatments in altruism” Good Samaritan Hospital, May 21, 2006.
• ADHD – conference sponsored by Dayton Association for Young Children, “Trends in early childhood education”, University of Dayton.
                                              

Emmett H. Broxson, MD 

• “Pediatric oncology, my perspective”, Candlelighters, Children’s Medical Center January 26, 2006.
• “Anemia and lead poisoning”, family practice residents, Miami Valley Hospital, March 29, 2006.
• “Pediatric oncology 2006: an overview” Grand Rounds, Reid Hospital, Richmond Indiana, May 10, 2006.
• “Hematology emergencies”, Annual Acute Care Symposium, Children’s Medical Center, August 16, 2006.
• “Pediatric oncology 2006: an overview”, Yankee Trace Golf Course, November 11, 2006.
• “Challenges of childhood cancer survivorship”, Grand Rounds, Children’s Medical Center, November 15, 2006.

Ann Burke, MD 

• “Making pediatrics family friendly" Speaker at Topic Symposium, PAS  May 1, 2006. 

Ryan Carvalho, MD

• "Inflammatory bowel disease new tests and therapies" Grand Rounds, CMC. 
• CCGA Sponsored Public Access Show on DATV: Patient Education on IBD.

Mukund Dole, MD 

• “Blood module”, WSU, November 15, 2006.
• “Sickle cell anemia”, Grand Rounds, CMC, November 9, 2006.
• “Recent advances in the management of iron overload”, Grand Rounds, CMC, December 6, 2006.
  

Shalini Forbis, MD    

• Cincinnati Children’s Hospital Grand Rounds, “Health literacy issues in the healthcare setting”, co-presenter, November 21, 2006.  
  

Adam Mezoff, MD 

• "Celiac disease" Grand Rounds, Dayton Children’s, February 9, 2005.
• "Principles of disease" WSU Boonshoft School of Medicine Course for Year I: GI Infections, May 20, 2005.
• "GERD in children" Residents Core Conference, Dayton Children’s, June 29, 2005.
• "Growth curves" Residents Morning Conference, Dayton Children’s, July 22, 2005.
• Organized, moderated and participated in Resident Career Night, Dayton Children’s, October 2005.

Gary Mueller, MD 

• “Pediatric asthma update”, Nursing CME presentation for hospital and community nursing, May 2005.       

Gary Onady, MD, PhD 

• Management of dyspnea in cystic fibrosis.  June 2006, VA resident Forum, Dayton, OH. June 2006.
• Case based study of insulin and various oral agents in the management of cystic fibrosis related diabetes.  Boonshoft School of Medicine, Wright State University Central Research Forum, February 7, 2006.

Marc Raslich, MD 

• “Teaching and learning styles”  Kettering Medical Center; Internal Medicine Faculty Development Workshop.  January 2006.

Michael Steffan, MD 

• "Sleep medicine services”.  Presentation to Kettering Youth Services (KYS), Kettering OH, January 30, 2006.
• “Sleepwalking, sleep terrors, and things that go bump in the night”.  What’s Up, Doc?  Meeting sponsored by the CMC Women’s Board, Sycamore Creek Country Club, Springboro OH.  May 4, 2006.
• “Safe sleep: the changing epidemiology of SIDS”.  Dayton Children's Nursing Open House.  November 8, 2006.
• “Common sleep disorders in children”.  Presentation to Child Psychiatry Fellows.  Elizabeth Place.  Dayton, OH, November 16, 2006.

Amit Vohra, MD        

• “Collaborative management of child with an acute illness” WSU Nursing Symposium, May 13, 2006.
• “Respiratory failure” Acute Care Symposium, July 12, 2006.
• “Pediatric organ donation” Grand Rounds at Dayton Childrens, October 25, 2006.

Teaching awards and other honors

Ann Burke, MD - APA Educational Scholars Program

Maria Nanagas, MD - Top Ten Women of Dayton 2006, Dayton Daily News Community Award

John Pascoe, MD - Recipient, 2006 Ellen Ruby Clore Excellence in Research Writing Award, Journal of Pediatric Health Care.

Gregory Toussaint, MD - 2006 Annual Resident Martha Franz Teaching Excellence Award; 2006 WSU-BSOM Annual Teaching Excellence Award from Class of 2007 as Outstanding MS-III attending

Maria Urban, MD - Elected by peers to “Best Doctors in America” for year 2006; Endocrinology course was again “one of the best organized and informative courses” per student’s evaluations.

Pediatric Intensive Care Unit. Awarded Dayton Children’s Pediatric Resident “Best Clinical Rotation” for education and experience.  Resident Graduation, June 2005.
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Nursing Research 2005-2006

• Cindy Asher, RN, CNS; Me